Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1.

Chen HC.

Nutr Metab (Lond). 2006 Jan 31;3:10.

PMID: 16448557 [PubMed - in process]

Related Articles Free article in PMC

Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.

Chen HC, Farese RV Jr.

Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):482-6. Epub 2004 Nov 29. Review.

PMID: 15569818 [PubMed - indexed for MEDLINE]

Related Articles

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV Jr.

J Clin Invest. 2003 Jun;111(11):1715-22.

PMID: 12782674 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr.

J Clin Invest. 2002 Apr;109(8):1049-55.

PMID: 11956242 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.

Streeper RS, Koliwad SK, Villanueva CJ, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E388-94. Epub 2006 Apr 4.

PMID: 16595853 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.

Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV Jr.

Diabetes. 2002 Nov;51(11):3189-95.

PMID: 12401709 [PubMed - indexed for MEDLINE]

Related Articles

Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.

Chen HC, Ladha Z, Farese RV Jr.

Endocrinology. 2002 Aug;143(8):2893-8.

PMID: 12130553 [PubMed - indexed for MEDLINE]

Related Articles

Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.

Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV Jr, Farese RV.

Diabetes. 2004 Jun;53(6):1445-51.

PMID: 15161747 [PubMed - indexed for MEDLINE]

Related Articles

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.

Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr.

Nat Genet. 2000 May;25(1):87-90.

PMID: 10802663 [PubMed - indexed for MEDLINE]

Related Articles

Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.

Chen HC, Ladha Z, Smith SJ, Farese RV Jr.

Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E213-8. Epub 2002 Sep 3.

PMID: 12388146 [PubMed - indexed for MEDLINE]

Related Articles

DGAT and triglyceride synthesis: a new target for obesity treatment?

Chen HC, Farese RV Jr.

Trends Cardiovasc Med. 2000 Jul;10(5):188-92. Review.

PMID: 11282293 [PubMed - indexed for MEDLINE]

Related Articles

Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

Liu L, Zhang Y, Chen N, Shi X, Tsang B, Yu YH.

J Clin Invest. 2007 Jun;117(6):1679-89. Epub 2007 May 17.

PMID: 17510710 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Choi CS, Savage DB, Kulkarni A, Yu XX, Liu ZX, Morino K, Kim S, Distefano A, Samuel VT, Neschen S, Zhang D, Wang A, Zhang XM, Kahn M, Cline GW, Pandey SK, Geisler JG, Bhanot S, Monia BP, Shulman GI.

J Biol Chem. 2007 Aug 3;282(31):22678-88. Epub 2007 May 27.

PMID: 17526931 [PubMed - indexed for MEDLINE]

Related Articles

Whole-body insulin resistance in the absence of obesity in FVB mice with overexpression of Dgat1 in adipose tissue.

Chen N, Liu L, Zhang Y, Ginsberg HN, Yu YH.

Diabetes. 2005 Dec;54(12):3379-86.

PMID: 16306352 [PubMed - indexed for MEDLINE]

Related Articles

Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin.

Meegalla RL, Billheimer JT, Cheng D.

Biochem Biophys Res Commun. 2002 Nov 1;298(3):317-23.

PMID: 12413942 [PubMed - indexed for MEDLINE]

Related Articles

Expression of DGAT2 in white adipose tissue is regulated by central leptin action.

Suzuki R, Tobe K, Aoyama M, Sakamoto K, Ohsugi M, Kamei N, Nemoto S, Inoue A, Ito Y, Uchida S, Hara K, Yamauchi T, Kubota N, Terauchi Y, Kadowaki T.

J Biol Chem. 2005 Feb 4;280(5):3331-7. Epub 2004 Nov 18.

PMID: 15550388 [PubMed - indexed for MEDLINE]

Related Articles

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis.

Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp FF Jr, Burri BJ, Hamilton RL, Abumrad NA, Farese RV Jr.

J Biol Chem. 2002 Jul 12;277(28):25474-9. Epub 2002 Apr 16.

PMID: 11959864 [PubMed - indexed for MEDLINE]

Related Articles

Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.

Chen HC, Smith SJ, Tow B, Elias PM, Farese RV Jr.

J Clin Invest. 2002 Jan;109(2):175-81.

PMID: 11805129 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC

Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

Yamazaki T, Sasaki E, Kakinuma C, Yano T, Miura S, Ezaki O.

J Biol Chem. 2005 Jun 3;280(22):21506-14. Epub 2005 Mar 29.

PMID: 15797871 [PubMed - indexed for MEDLINE]

Related Articles

Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.

Wang SJ, Cornick C, O'Dowd J, Cawthorne MA, Arch JR.

Lipids Health Dis. 2007 Jan 19;6:2.

PMID: 17239230 [PubMed - indexed for MEDLINE]

Related Articles Free article in PMC