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1: Eur J Pharmacol. 1992 Jan 21;210(3):343-6.
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L-canavanine selectively augments contraction in aortas from endotoxemic rats.

Umans JG, Samsel RW.

Department of Medicine, University of Chicago, IL 60637.

Contractile responses to KCl or phenylephrine were inhibited in endothelium-denuded aorta from endotoxin-treated rats. L-Canavanine, a selective inhibitor of inducible nitric oxide synthase, augmented contractile responses in vessels from endotoxin, but not saline-pretreated animals. In contrast to nitroarginine, L-canavanine did not inhibit endothelium-dependent relaxation induced by acetylcholine. Selective inhibitors of inducible nitric oxide synthase may be useful probes of vascular dysfunction in sepsis.

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PMID: 1612105 [PubMed - indexed for MEDLINE]