Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening
1 Programa de Pós Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brasil
2 Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brasil
3 Grupo Brasileiro de Estudos do Câncer de Mama (GBECAM), São Paulo, Brasil
4 Programa de Pós Graduação em Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brasil
5 Laboratório de Medicina Genômica do Hospital de Clínicas de Porto Alegre (HCPA), Rio Grande do Sul, Brasil
6 Instituto Nacional de Genética Médica Populacional (INAGEMP), Porto Alegre, Brasil
7 Laboratório Nobel Sociedade Simples Ltda, Rio Grande do Sul, Brasil
8 Núcleo Mama Porto Alegre (NMPOA), Rio Grande do Sul, Brasil
9 Departamento de Patologia, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brasil
10 Departamento de Genética, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brasil
11 Hospital de Clinicas de Porto Alegre (HCPA), , Rio Grande do Sul, Brazil
Nutrition & Metabolism 2012, 9:97 doi:10.1186/1743-7075-9-97Published: 31 October 2012
The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis.
To investigate the relationship between anthropometric profile, dietary intake, lipid profile and fasting glycemia with serum levels of adipokines (adiponectin and PAI-1) and adhesion molecules (ICAM-1 and VCAM-1) in women without breast cancer undergoing routine mammographic screening.
One hundred and forty-five women over 40-years old participated in this study.
In 39.3% of cases the BMI was above 30 kg/m2; 46.9% had hypertension, 14.5% had type 2 Diabetes Mellitus, 31.7% had dyslipidemia and 88.3% presented a waist-to-hip ratio ≥ 0.8. A linear correlation was found between serum levels of PAI-1 and triglycerides, between serum levels of PAI-1 and WHR and between serum levels of VCAM-1 and BMI.
We found a high prevalence of obesity and metabolic syndrome. PAI-1 and VCAM-1 levels were correlated with clinical indicators of obesity and overweight.