Open Access Research

Association of adipokines and adhesion molecules with indicators of obesity in women undergoing mammography screening

Caroline Isoppo de Souza1, Daniela Dornelles Rosa1,2,3*, Betina Ettrich1, Gabriela Hermann Cibeira1,4, Juliana Giacomazzi1,5, Paloma Tusset1, Patrícia Ashton-Prolla1,10,5,6, Lidia Rosi Medeiros1, Maira Caleffi3,4,8, Eurico Camargo Neto7, Emilio Hideyuki Moriguchi4 and Marcia Silveira Graudenz1,11,9

Author Affiliations

1 Programa de Pós Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brasil

2 Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brasil

3 Grupo Brasileiro de Estudos do Câncer de Mama (GBECAM), São Paulo, Brasil

4 Programa de Pós Graduação em Cardiologia e Ciências Cardiovasculares, Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul, Brasil

5 Laboratório de Medicina Genômica do Hospital de Clínicas de Porto Alegre (HCPA), Rio Grande do Sul, Brasil

6 Instituto Nacional de Genética Médica Populacional (INAGEMP), Porto Alegre, Brasil

7 Laboratório Nobel Sociedade Simples Ltda, Rio Grande do Sul, Brasil

8 Núcleo Mama Porto Alegre (NMPOA), Rio Grande do Sul, Brasil

9 Departamento de Patologia, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brasil

10 Departamento de Genética, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brasil

11 Hospital de Clinicas de Porto Alegre (HCPA), , Rio Grande do Sul, Brazil

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Nutrition & Metabolism 2012, 9:97 doi:10.1186/1743-7075-9-97

Published: 31 October 2012

Abstract

Background

The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis.

Objective

To investigate the relationship between anthropometric profile, dietary intake, lipid profile and fasting glycemia with serum levels of adipokines (adiponectin and PAI-1) and adhesion molecules (ICAM-1 and VCAM-1) in women without breast cancer undergoing routine mammographic screening.

Design

Transversal study.

Subjects

One hundred and forty-five women over 40-years old participated in this study.

Results

In 39.3% of cases the BMI was above 30 kg/m2; 46.9% had hypertension, 14.5% had type 2 Diabetes Mellitus, 31.7% had dyslipidemia and 88.3% presented a waist-to-hip ratio ≥ 0.8. A linear correlation was found between serum levels of PAI-1 and triglycerides, between serum levels of PAI-1 and WHR and between serum levels of VCAM-1 and BMI.

Conclusion

We found a high prevalence of obesity and metabolic syndrome. PAI-1 and VCAM-1 levels were correlated with clinical indicators of obesity and overweight.

Keywords:
Obesity; Adiponectin; Plasminogen Activator Inhibitor type-1; Vascular Cell Adhesion Molecule-1; Intercellular Adhesion Molecule-1