Email updates

Keep up to date with the latest news and content from Nutrition & Metabolism and BioMed Central.

Open Access Research

D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

Binbing Ling, Fei Peng, Jane Alcorn, Katharina Lohmann, Brian Bandy and Gordon A Zello*

Nutrition & Metabolism 2012, 9:6  doi:10.1186/1743-7075-9-6

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Complex effects of D-lactate

Heikki Savolainen   (2012-07-04 16:43)  Ministry of Social Affairs and Health email

Dear Editor,

Ling et al. (1) show convincingly that highly oxygen-depedent organs are more prone to the toxic effects of D-lactate than liver.

However, dosing of D-lactate in a liver cell culture has other very interesting effects. Namely, the PI3K/AktPKB/PKC acitivity is decreased which leads to low BAD activity allowing increased apoptosis (2).

This indicates that D-lactate can also have other significant metabolic effects e.g. in diabetics who have increased D-lactate burden because of excessive methylglyoxal from glucose (3).

1 Ling et al. Nutrition and Metab 2012; 9: 6

2 Miyamato. J Am Coll Surg 2007; 204: 182

3 Talasniemi et al. Clin Biochem 2008; 41: 1099

Competing interests



Post a comment