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D-Lactate altered mitochondrial energy production in rat brain and heart but not liver

Binbing Ling, Fei Peng, Jane Alcorn, Katharina Lohmann, Brian Bandy and Gordon A Zello*

Nutrition & Metabolism 2012, 9:6  doi:10.1186/1743-7075-9-6

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Complex effects of D-lactate

Heikki Savolainen   (2012-07-04 16:43)  Ministry of Social Affairs and Health email

Dear Editor,

Ling et al. (1) show convincingly that highly oxygen-depedent organs are more prone to the toxic effects of D-lactate than liver.

However, dosing of D-lactate in a liver cell culture has other very interesting effects. Namely, the PI3K/AktPKB/PKC acitivity is decreased which leads to low BAD activity allowing increased apoptosis (2).

This indicates that D-lactate can also have other significant metabolic effects e.g. in diabetics who have increased D-lactate burden because of excessive methylglyoxal from glucose (3).

1 Ling et al. Nutrition and Metab 2012; 9: 6

2 Miyamato. J Am Coll Surg 2007; 204: 182

3 Talasniemi et al. Clin Biochem 2008; 41: 1099

Competing interests

None

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