Table 5

Studies outlining the effects of supplementing dietary arachidonic acid on changes in plasma/serum phospholipid arachidonic acid level

Author, (reference)

Study design

Subjects

Diet length

AA source, amount supplemented (g/d)

Δ AA (%) change

Comments


Sinclair [54]

Parallel intervention

N = 4

7 days

White meat/eggs (0.50)

52 (p < 0.05)

Consumed AA rich, low fat diet

Ishikura [55]

Double-blind crossover

N = 25

1 month

SUNTGA40S capsules (0.72)

27 (p < 0.05)

Derived from Mortierella alpina

Theis [45]

Randomized, double-blind, parallel intervention

N = 48

12 weeks

ARASCO (0.68)

85 (p < 0.05)

Derived from Mortierella alpina

Kusmoto [56]

Double-blind intervention

N = 12

4 weeks

SUNTGA40S (0.84)

45 (p < 0.05)

Derived from Mortierella alpina

Nelson [57]

Single blind crossover intervention

N = 10

50 days

ARASCO (1.49)

85 (p < 0.05)

Had 65 day washout period. Derived from Mortierella alpina

Seyberth [58]

Single blind intervention

N = 4

2-3 weeks, depending upon subject

Capsules, AA ethyl ester (6.00)

136 (p < 0.05)

Averaged from all 4 subjects


Percent change (±) from baseline in AA that is significant is identified with (p < 0.05). Percent change (±) from baseline in AA that is not significant is denoted by N.S.

Abbreviations: AA, arachidonic acid

Rett and Whelan Nutrition & Metabolism 2011 8:36   doi:10.1186/1743-7075-8-36

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