Research
Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study
-
* Corresponding author: Jong Ho Lee jhleeb@yonsei.ac.kr
- † Equal contributors
1 Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea
2 Clinical Nutrigenetics/Nutrigenomics Lab, Dept of Food and Nutrition, Yonsei University, Seoul, Korea
Nutrition & Metabolism 2011, 8:24 doi:10.1186/1743-7075-8-24
Published: 23 April 2011Additional files
Additional file 1:
Genotype and haplotype distribution of study population. It included genotype and haplotype distribution of 4 SNPs (FEN1-10154 rs174537G>T, FADS2 rs174575C>G, FADS2 rs2727270C>T and FADS3 1000778C>T) in the whole study subjects. The selected 4 SNPs satisfied the HWE (P > 0.05): minor T allele frequency of FEN1-10154 rs174537G>T was 0.312, minor G allele frequency of FADS2 rs174575C>G was 0.082, minor T allele frequency of FADS2 rs2727270C>T was 0.24, and minor T allele frequency of FADS3 1000778C>T was 0.293. This file also included the haplotype distribution of rs174537-rs174575-rs2727270-rs1000778: GCCC was the most highly frequent haplotype and the nonGCCC frequency was 0.450.
Format: DOCX Size: 14KB Download file
Additional file 2:
Macro-nutrient intake and energy expenditure of study population according to FEN1 -10154G>T, FADS2 rs174575, FADS2 rs2727270 and rsFADS3 1000778C>T. It included the information of Macro-nutrient intake and energy expenditure according to the genotypes of the FEN1 -10154G>T, FADS2 rs174575C>G, FADS2 rs2727270C>T and FADS3 rs1000778C>T, respectively. No significant genotype-associated differences were observed for total energy intake, proportions of energy intake derived from carbohydrates and fat in each of 4 FADS SNPs.
Format: DOCX Size: 17KB Download file