Open Access Research

Association of high sensitive C-reactive protein (hsCRP) with established cardiovascular risk factors in the Indian population

Panniyammakal Jeemon128, Dorairaj Prabhakaran28*, Lakhmy Ramakrishnan3, Ruby Gupta3, F Ahmed4, KR Thankappan5, CC Kartha6, Vivek Chaturvedi7, KS Reddy8 and the Sentinel Surveillance in Industrial Populations Study Group

Author Affiliations

1 Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK

2 Centre for Chronic Disease Control, New Delhi, India

3 All India Institute of Medical Sciences, New Delhi, India

4 KPC Medical College, Jadavpur, Kolkata, India

5 Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, India

6 Rajiv Gandhi Center for Biotechnology, Trivandrum, India

7 GB Pant Hospital, New Delhi, India

8 Public Health Foundation of India, New Delhi, India

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Nutrition & Metabolism 2011, 8:19  doi:10.1186/1743-7075-8-19

Published: 28 March 2011

Abstract

Introduction

Inflammation, the key regulator of C-reactive protein (CRP) synthesis, plays a pivotal role in atherothrombotic cardiovascular disease.

Methods

High sensitivity CRP (hsCRP) analysis was carried out in randomly selected 600 individuals from the sentinel surveillance study in Indian industrial population (SSIP). The hsCRP was measured quantitatively by turbid metric test using kits from SPINREACT, Spain. We analyzed the association between hsCRP and traditional CVD risk factors in this sub-sample.

Results

Complete risk factor data and CRP levels were available from 581/600 individuals. One half (51.2%) of the study subjects were males. Mean age of the study group was 39.2 ± 11.2 years. The Pearson correlation coefficients were in the range of 0.12 for SBP (p = 0.004) to 0.55 for BMI (p < 0.001). The linear regression coefficients ranged from 0.01 for SBP, PG and TC (p < 0.001) to 0.55 for logeTAG (p < 0.001) after adjustment for age, sex and education. The mean of logehsCRP significantly increased (P < 0.001) from individuals with ≤1 risk factors (-0.50) to individuals with three or more risk factors (0.60). In the multivariate model, the odds ratios for elevated CRP (CRP ≥ 2.6 mg/dl) were significantly elevated only in females in comparison to males (1.63, 95% CI; 1.02-2.58), overweight individuals in comparison to normal weight individuals (3.90, 95% CI; 2.34-6.44, p < 0.001), and abdominal obese individuals (1.62, 95% CI; 1.02-2.60, p = 0.04) in comparison to non-obese individuals.

Conclusion

Clinical measurements of adiposity (body mass index and abdominal obesity) correlate well and can be surrogate for systemic inflammatory state of individuals.