Table 2 |
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Effect of consecutive ingestion of Guava Leaf Tea on serum parameters of carbohydrate metabolism in pre- and mild diabetic patients and diabetic patients with T2DM under anti-diabetic medication |
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|
Serum parameter |
Pre- and mild diabetic patients 1) |
Type 2 diabetic patients 2) |
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|
|
|
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|
n |
Initial week |
Week 12 |
n3) |
Initial week |
Week 8 |
|
|
|
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|
FBG (mg/dL) |
15 |
136 ± 22 |
131 ± 25 #1 |
21 |
183 ± 71 |
171 ± 76 |
|
111-127 mg/dL |
7 |
118 ± 7 |
112 ± 6 #2 |
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|
Reduction rate of FBG (%) |
15 |
0 |
4.3 ± 7.6* |
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|
HbA1c(%) |
15 |
6.1 ± 0.7 |
6.2 ± 0.8 |
22 |
7.4 ± 1.4 |
7.4 ± 1.3 |
|
≧ 6.5% |
15 |
8.1 ± 1.1 |
7.8 ± 1.1* |
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|
Insulin (μU/mL) |
15 |
9.0 ± 3.0 |
7.0 ± 2.0** |
19 |
28.7 ± 26.3 |
21.5 ± 18.0 |
|
≧ 17 μU/mL |
11 |
43.6 ± 25.5 |
27.5 ± 19.4* |
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|
HOMA-IR |
15 |
3.1 ± 1.3 |
2.3 ± 1.0** |
19 |
12.2 ± 9.9 |
10.8 ± 13.0 |
|
|
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1) Guava Leaf Tea (190 ml/bottle) was ingested 3 times/day with each meal for 12 weeks by pre-diabetic and mild type 2 diabetic subjects who were 15 males, over 45 years of age and who had an FBG level of 110 mg/dL or higher and a BMI of >22.0. 2) Guava Leaf Tea (200 ml/bottle) was ingested 3 times/day with every meal for 8 weeks by 22 patients with T2DM who had a blood HbA1c% of >6.0% before intake. Of these 22 patients, 19 received anti-diabetic medication (insulin, sulfonylurea and/or alpha-GI) throughout the trial. Three patients with hypercholesterolemia were also administered fluvastatin, an inhibitor of HMG-CoA reductase in addition to an anti-diabetic drug throughout the trial. 3) Some data under the no fasting condition are omitted. Values are expressed as mean ± SD. *: p < 0.05, **: p < 0.01, #1: p = 0.07, #2: p = 0.06 (Dunnett's multiple paired test). Reproduced from [15,32] with some modifications. |
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Deguchi and Miyazaki Nutrition & Metabolism 2010 7:9 doi:10.1186/1743-7075-7-9 |
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