Table 1

Genes with significant differential expression in animals fed a KD versus those fed SD.

SD Expression

KD Expression

Gene Symbol

Gene Name

Non-Tumor

Tumor

Non-Tumor

Tumor

Ptgs2 (Cox2)

Prostaglandin-endoperoxide synthase 2 (cyclooxygenase 2)

0.732 ± 0.035

0.364 ± 0.01

13.19 ± 5.24

0.41 ± 0.20

Cyga

Cytochrome b-245, alpha polypeptide

5.5 ± 10.86

10.24 ± 0.05

3.79 ± 0.41

13.3 ± 1.31

Cygb

Cytoglobin

8.02 ± 0.06

1.20 ± 0.09

6.53 ± 0.62

1.96 ± 0.01

Gpx3

Glutathione peroxidase 3

9.72 ± 1.33

4.75 ± 0.62

13.16 ± 0.75

5.72 ± 0.54

Gpx7

Glutathione peroxidase 7

2.82 ± 0.14

15.1 ± 0.91

2.18 ± 0.35

23.5 ± 3.07

Gstk1

Glutathione S-transferase kappa 1

8.36 ± 1.13

13.21 ± 1.51

5.83 ± 0.43

13.79 ± 0.56

Ncf2

Neutrophil cytosolic factor 2

1.04 ± 0.02

2.63 ± 0.30

1.31 ± 0.06

3.53 ± 0.25

Ngb

Neuroglobin

3.01 ± 0.02

0.922 ± 0.10

4.06 ± 0.13

1.61 ± 0.01

Noxo1

NADPH oxidase organizer 1

0.56 ± 0.00

1.54 ± 0.31

0.46 ± 0.01

1.54 ± 0.03

Nqo1

NAD(P)H dehydrogenase, quinone

1.75 ± 0.10

0.85 ± 0.03

1.71 ± 0.01

0.744 ± 0.01

Prdx4

Peroxiredoxin 4

2.71 ± 0.21

14.04 ± 0.11

2.48 ± 0.41

19.68 ± 4.01

Prnp

Prion protein

74.09 ± 0.04

21.46 ± 1.43

70.42 ± 9.03

23.17 ± 6.71

Scd1

Stearoyl-Coenzyme A desaturase 1

163.1 ± 5.1

83.65 ± 0.15

163.3 ± 22.16

88.54 ± 4.41

Serpinb1b

Serine (or cysteine) peptidase inhibitor, clade B, member 1b

2.91 ± 0.11

0.39 ± 0.15

3.12 ± 1.53

0.41 ± 0.13

Srxn1

Sulfiredoxin 1 homolog (S. cerevisiae)

0.56 ± 0.00

0.068 ± 0.01

1.17 ± 0.05

0.88 ± 0.02

Txnip

Thioredoxin interacting protein

9.82 ± 1.31

19.66 ± 1.15

8.71 ± 0.46

23.3 ± 1.56

Txnrd1

Thioredoxin reductase 1

15.17 ± 2.54

64.70 ± 1.71

15.69 ± 1.85

46.67 ± 1.33

Vim

Vimentin

15.17 ± 2.23

160.60 ± 3.31

55.58 ± 10.12

140.3 ± 2.24

Expression values are normalized to the 50^th percentile per array.

Stafford et al. Nutrition & Metabolism 2010 7:74   doi:10.1186/1743-7075-7-74