Nutrition & Metabolism

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Open Access Research

Identification of the Eph receptor pathway as a novel target for eicosapentaenoic acid (EPA) modification of gene expression in human colon adenocarcinoma cells (HT-29)

Joanne F Doleman*, John J Eady, Ruan M Elliott, Rob J Foxall, John Seers, Ian T Johnson and Elizabeth K Lund

Author Affiliations

Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK

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Nutrition & Metabolism 2010, 7:56 doi:10.1186/1743-7075-7-56

Published: 12 July 2010

Additional files

Additional file 1:

Table S1. Table of significantly altered genes as identified in R from microarray. A table showing all the significantly modified genes as identified in R from microarray data at each time point along with their corresponding p-value, adjusted p-value, GenBank ID, Unigene ID and a gene description.

Format: XLS Size: 366KB Download file

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Additional file 2:

Figure S1. Simplified Ephrin receptor network from MetaCore. The Ephrin receptor network as constructed by MetaCore showing genes significantly altered by EPA treatment of HT29 cells as determined by microarray analysis in R.

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Additional file 3:

Table S2. List of top ten significantly modified pathways as identified in MetaCore. A table showing the top ten ranked pathways as identified in MetaCore along with their corresponding p-value

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Additional file 4:

Figure S2. Cell Adhesion and Ephrins Signalling Pathway from MetaCore. A pathway map from MetaCore showing the Cell Adhesion and Ephrin signalling pathway which contains many significantly modified genes as a result of EPA treatment as determined by microarray analysis.

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Open Data