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Circulating omentin concentration increases after weight loss

José María Moreno-Navarrete13, Victoria Catalán23, Francisco Ortega13, Javier Gómez-Ambrosi23, Wifredo Ricart13, Gema Frühbeck23 and José Manuel Fernández-Real13*

Author Affiliations

1 Service of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi) Hospital Dr Josep Trueta, Girona, 17007, CIBEROBN (CB06/03/010), Spain

2 Department of Endocrinology & Metabolic Research Laboratory, Clínica Universitaria de Navarra Pamplona, 31008, CIBEROBN (CB06/03/1014), Spain

3 Instituto de Salud Carlos III (ISCIII) Madrid, 28029, Spain

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Nutrition & Metabolism 2010, 7:27  doi:10.1186/1743-7075-7-27

Published: 9 April 2010



Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations.


Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss.


Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p < 0.001), body weight (r = -0.35, p = 0.045), fat mass (r = -0.67, p < 0.001), circulating leptin (r = -0.7, p < 0.001) and fasting insulin (r = -0.37, p = 0.03). Circulating omentin-1 concentration increased significantly after weight loss (from 44.9 ± 9.02 to 53.41 ± 8.8 ng/ml, p < 0.001). This increase in circulating omentin after weight loss was associated with improved insulin sensitivity (negatively associated with HOMA value and fasting insulin, r = -0.42, p = 0.02 and r = -0.45, p = 0.01, respectively) and decreased BMI (r = -0.54, p = 0.001).


As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.