Table 1 |
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|
Anthropometric and biochemical characteristics of studied subjects. |
||||
|
Non-obese |
Obese |
Morbidly Obese |
p |
|
|
|
||||
|
N |
39 |
17 |
34 |
|
|
Sex (M/F) |
15/24 |
6/11 |
10/24 |
0.72 |
|
Body Mass Index (kg/m2) |
25.4 ± 3.5 |
35.3 ± 3.1 |
46.1 ± 5.5 |
< 0.0001 |
|
Age (years) |
46.7 ± 13.7 |
53.1 ± 14.9 |
43.1 ± 11 |
0.03 |
|
Glucose (mg/dl) |
93.8 ± 32.2 |
91.25 ± 11.8 |
124.8 ± 59.4 |
0.005 |
|
Cholesterol (mg/dl) |
195.5 ± 41.5 |
182.2 ± 34.8 |
189 ± 31.6 |
0.47 |
|
LDL-cholesterol (mg/dl) |
118 ± 35.8 |
99.6 ± 32.1 |
110.8 ± 36.7 |
0.27 |
|
HDL-cholesterol (mg/dl) |
57.2 ± 16.7 |
54.5 ± 16.9 |
59.15 ± 58.7 |
0.93 |
|
Log fasting tryglicerides |
1.98 ± 0.2 |
2.03 ± 0.2 |
2.11 ± 0.2 |
0.08 |
|
ACACA visceral (RU) |
0.04 ± 0.01 |
0.017 ± 0.003 |
0.02 ± 0.001 |
0.001 |
|
ACACA subcutaneous (RU)* |
0.033 ± 0.006 |
0.015 ± 0.002 |
0.02 ± 0.002 |
0.03 |
|
FASN visceral (RU) |
0.16 ± 0.02 |
0.07 ± 0.01 |
0.09 ± 0.01 |
0.02 |
|
FASN subcutaneous (RU)* |
0.36 ± 0.14 |
0.07 ± 0.02 |
0.06 ± 0.009 |
0.01 |
|
SREBP-1c visceral (RU) |
0.018 ± 0.002 |
0.013 ± 0.001 |
0.014 ± 0.001 |
0.2 |
|
SREBP-1c subcutaneous (RU)* |
0.019 ± 0.004 |
0.009 ± 0.001 |
0.009 ± 0.001 |
0.04 |
|
Spot-14 visceral (RU) |
0.26 ± 0.03 |
0.26 ± 0.03 |
0.23 ± 0.01 |
0.6 |
|
Spot-14 subcutaneous (RU)* |
0.60 ± 0.05 |
0.45 ± 0.003 |
0.48 ± 0.03 |
0.04 |
|
Caveolin visceral (RU) |
1.68 ± 0.9 |
1.04 ± 0.3 |
1.05 ± 0.3 |
< 0.0001 |
|
Caveolin subcutaneous (RU)* |
1.50 ± 0.4 |
1.78 ± 0.8 |
1.44 ± 0.4 |
0.22 |
|
|
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|
ACACA, acetyl coA carboxylase; FAS, fatty acid synthase; SREBP-1c, sterol-regulatory-element-binding protein; RU, relative units. Values are expressed as mean ± SD except for gene expressions that are expressed as mean ± SEM. *Subcutaneous adipose samples were studied in 16 non-obese, 13 obese and 26 morbidly obese subjects. |
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|
Fernández-Real et al. Nutrition & Metabolism 2010 7:20 doi:10.1186/1743-7075-7-20 |
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