Nutrition & Metabolism

official impact factor 2.35

Open Access Research

Different responsiveness to a high-fat/cholesterol diet in two inbred mice and underlying genetic factors: a whole genome microarray analysis

Mingzhe Zhu1,6, Guozhen Ji2, Gang Jin3,4,1* and Zuobiao Yuan1,5*

Author Affiliations

1 Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

2 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China

3 ShanghaiBio Corporation, 675 US Highway One, North Brunswick, NJ, USA

4 Shanghai Biochip Co., Ltd and National Engineering Center for Biochip at Shanghai, Shanghai, PR China

5 Department of Surgery, University of Iowa, Iowa City, USA

6 Graduate School of the Chinese Academy of Sciences, Shanghai, China

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Nutrition & Metabolism 2009, 6:43 doi:10.1186/1743-7075-6-43

Published: 17 October 2009

Additional files

Additional file 1:

Table S1, Primers for quantitative real-time-PCR. Primers for quantitative real-time-PCR.

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Additional file 2:

Figure S1, Atherosclerotic lesions and the weight of gallstones. Atherosclerotic lesions at the 21st week and the weight of gallstones at each time-point in B6 mice.

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Additional file 3:

Table S2, Differentially expressed genes. Log2ratio was calculated between 0 week and the rest of time points in each mouse strains.

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Additional file 4:

Figure S2. Function categories of further analysis genes. Categories of functions in differentially expressed genes.

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Additional file 5:

Table S3, Detailed pathways information. Detailed pathways identified in differentially expressed genes and detailed information of their corresponding genes.

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Additional file 6:

Figure S3. Hierarchical cluster analysis. Hierarchical cluster analysis was performed using log2ratios calculating between B6 and D2 at each time point. Samples (five time points) are displayed in columns and genes are displayed in rows.

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