Different responsiveness to a high-fat/cholesterol diet in two inbred mice and underlying genetic factors: a whole genome microarray analysis

doi:10.1186/1743-7075-6-43

Nutrition & Metabolism

Volume 6

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Different responsiveness to a high-fat/cholesterol diet in two inbred mice and underlying genetic factors: a whole genome microarray analysis

Mingzhe Zhu¹^,6 , Guozhen Ji² , Gang Jin¹^,3^,4 and Zuobiao Yuan¹^,5

¹Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

²Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China

³ShanghaiBio Corporation, 675 US Highway One, North Brunswick, NJ, USA

⁴Shanghai Biochip Co., Ltd and National Engineering Center for Biochip at Shanghai, Shanghai, PR China

⁵Department of Surgery, University of Iowa, Iowa City, USA

⁶Graduate School of the Chinese Academy of Sciences, Shanghai, China

author email corresponding author email

Nutrition & Metabolism 2009, 6:43doi:10.1186/1743-7075-6-43


Published:	17 October 2009

Additional files

Additional file 1:

Table S1, Primers for quantitative real-time-PCR. Primers for quantitative real-time-PCR.

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Additional file 2:

Figure S1, Atherosclerotic lesions and the weight of gallstones. Atherosclerotic lesions at the 21^stweek and the weight of gallstones at each time-point in B6 mice.

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Additional file 3:

Table S2, Differentially expressed genes. Log₂ratio was calculated between 0 week and the rest of time points in each mouse strains.

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Additional file 4:

Figure S2. Function categories of further analysis genes. Categories of functions in differentially expressed genes.

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Additional file 5:

Table S3, Detailed pathways information. Detailed pathways identified in differentially expressed genes and detailed information of their corresponding genes.

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Additional file 6:

Figure S3. Hierarchical cluster analysis. Hierarchical cluster analysis was performed using log₂ratios calculating between B6 and D2 at each time point. Samples (five time points) are displayed in columns and genes are displayed in rows.

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