Table 2 |
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|
Demographic Characteristics |
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|
Safety population |
AC-1202 N = 86 |
Placebo N = 66 |
|
|
|
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|
Age |
Mean (± SD) Median |
76.9 (± 8.9) 78.0 |
76.8 (± 7.4) 78.0 |
|
Range |
(52 – 93) |
(51 – 89) |
|
|
|
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|
Height (cms) |
Mean (± SD) |
165.2 (± 11.4) |
163.2 (± 16.4) |
|
Median |
163.8 |
164.6 |
|
|
Range |
(142.2 – 190.1) |
(114.3 – 185.4) |
|
|
|
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|
Weight (kg) |
Mean (± SD) |
69.0 (± 15.15) |
70.6 (± 13.7) |
|
Median |
69.2 |
67.8 |
|
|
Range |
(34.3 – 100.2) |
(47.6 – 100.2) |
|
|
|
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|
Sex n (%) |
Male |
36 (41.7) |
31 (47.0) |
|
Female |
50 (58.1) |
35 (53.0) |
|
|
|
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|
Race n (%) |
Caucasian |
78 (90.7) |
61 (92.4) |
|
Black |
1 (1.2) |
0 |
|
|
Hispanic |
7 (8.1) |
5 (7.6) |
|
|
|
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|
Level of Education n (%) |
Graduate/Professional Training |
17 (19.8) |
7 (10.6) |
|
Some college |
15 (17.4) |
17 (25.8) |
|
|
High School |
49 (57.0) |
34 (51.5) |
|
|
Grade School |
5 (5.8) |
8 (12.1) |
|
|
|
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|
AD medications n (%)* |
Aricept™ |
43 (50) |
28 (42.4) |
|
Exelon™ |
11 (12.8) |
11 (16.7) |
|
|
Namenda™ |
32 (37.2) |
31 (47) |
|
|
Reminyl™/Razadyne™ |
3 (3.5) |
9 (13.6) |
|
|
|
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|
Genotyped population |
AC-1202 N = 67 |
Placebo N = 57 |
|
|
|
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|
APOE Genotype n (%) |
3/2 |
4 (6.0) |
2 (3.5) |
|
3/3 |
25 (37.3) |
24 (42.1) |
|
|
4/2 4/3 |
3 (4.9) 31 (46.3) |
0 21 (36.8) |
|
|
4/4 |
4 (6.0) |
10 (17.5) |
|
|
Total E4(+) |
38 (56.7) |
31 (54.4) |
|
|
Total E4(-) |
29 (43.3) |
26 (45.6) |
|
|
|
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|
ITT population |
AC-1202 N = 77 |
Placebo N = 63 |
|
|
|
|||
|
Baseline MMSE |
Mean (± SD) |
19.68 (± 4.48) |
19.48 (± 4.37) |
|
Median |
20.00 |
20.00 |
|
|
Range |
(10 – 28) |
(8 – 29) |
|
|
95% CI |
18.66, 20.69 |
18.37, 20.58 |
|
|
|
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|
Baseline ADAS-Cog |
Mean (± SD) |
23.88 (± 9.17) |
23.35 (± 8.7) |
|
Median |
23.67 |
23.00 |
|
|
Range |
(7.00 – 54.33) |
(11.33 – 62.00) |
|
|
95% CI |
21.80, 25.96 |
21.16, 25.54 |
|
|
|
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|
*Some participants were on more than one AD medication |
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|
Henderson et al. Nutrition & Metabolism 2009 6:31 doi:10.1186/1743-7075-6-31 |
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