Table 4

Changes in HbA1c, BMI, serum lipids and creatinine, blood pressure and dose of antidiabetic drugs (n = 33)


Baseline
After 3 months
After 6 months
P

HbA1c (%)
10.9 ± 1.6 (9.0 – 14.4)
7.8 ± 1.5 (5.9 – 11.3)
7.4 ± 1.4 (5.5 – 12.7)
< 0.001
BMI
23.8 ± 3.3 (18.0 – 33.8)
23.5 ± 3.4 (16.8 – 32.8)
23.5 ± 3.4 (17.1 – 32.7)
0.057
Serum LDL-cholesterol (mg/dl)*
142 ± 50 (51 – 260)

128 ± 34 (61 – 213)
0.036
Serum HDL-cholesterol (mg/dl)*
52 ± 14 (30 – 77)

59 ± 16 (34 – 94)
0.008
Serum triglyceride (mg/dl)*
182 ± 189 (50 – 823)

157 ± 178 (34 – 721)
0.39
Serum creatinine (mg/dl)
0.68 ± 0.20 (0.38 – 1.20)

0.71 ± 0.21 (0.44 – 1.25)
0.21
Systolic BP (mmHg)
138 ± 17 (104 – 175)

135 ± 14 (97 – 157)
0.24
Diastolic BP (mmHg)
81 ± 11 (59 – 102)

81 ± 11 (48 – 113)
0.64
Patients with antidiabetic drugs (n)




     Glibenclamide
n = 6 (4.0 mg)
n = 3 (1.7 mg)
n = 1 (2.5 mg)

     Glimepiride
n = 1 (3.0 mg)
n = 2 (0.75 mg)
n = 0 (0 mg)

     Tolbutamide
n = 0 (0 mg)
n = 0 (0 mg)
n = 1 (500 mg)

     Metformin
n = 0 (0 mg)
n = 2 (500 mg)
n = 5 (600 mg)

     Nateglinide
n = 2 (135 mg)
n = 2 (180 mg)
n = 0 (0 mg)

     Pioglitazone
n = 0 (0 mg)
n = 0 (0 mg)
n = 2 (30 mg)

     Miglitol
n = 1 (150 mg)
n = 3 (100 mg)
n = 7 (125 mg)


HbA1c: hemoglobin A1c; BMI: body mass index; BP: blood pressure. Values are means ± SD. The numbers in parenthesis in HbA1c, BMI, serum lipids, serum creatinine and blood pressure indicate ranges, and those in antidiabetic drugs show a mean daily dose. Two drop-out patients are included in the analysis.

*: Four patients are excluded from serum lipids analysis because they received lipid-lowering drugs.

Haimoto et al. Nutrition & Metabolism 2009 6:21   doi:10.1186/1743-7075-6-21