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Genes and SNPs analyzed for associations with percent body fat change profiles for LF and LC groups. |
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| Area |
Pathway |
Gene |
Symbol |
SNP |
Type |
|
|
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| Food Intake |
Neural |
galanin |
GAL |
rs694066 |
intron 1 |
| leptin receptor |
LEPR |
rs7602 |
intron 1 (3' UTR on another gene) |
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| rs1171276 |
intron 1 (untranslated) |
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| rs8179183 |
exon 12, N656K |
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| melanocortin 3 receptor |
MC3R |
rs6024725 |
~10 kb upstream |
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| neuropeptide Y |
NPY |
rs1468271 |
intron 1 |
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| neuropeptide Y receptor Y5 |
NPY5R |
rs11100494 |
intron 3 |
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| rs6837793 |
~9 kb upstream |
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| Neural/Gut |
histamine N-methyltransferase |
HNMT |
rs1801105 |
exon 4, I105T |
|
| rs12691940 |
intron 2 |
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| Gut |
apolipoprotein A-IV |
APOA4 |
rs675 |
T367S, exon 3 |
|
| rs5092 |
exon 2, T29T |
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| ghrelin precursor |
GHRL |
rs26312 |
~1 kb upstream |
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| lipase, gastric |
LIPF |
rs814628 |
exon 4, A161T |
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| peptide YY |
PYY |
rs1058046 |
exon 2, R72T |
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| rs231460 |
~1.8 kb upstream |
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| Energy Homeostasis |
Metabolic Enzyme |
glycogen synthase kinase 3 beta |
GSK3B |
rs4688046 |
intron 3 |
| rs334555 |
intron 1 |
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| rs10934502 |
intron 2 |
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| glycogen synthase 1 (muscle) |
GYS1 |
rs2287754 |
5' UTR |
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| glycogen synthase 2 (liver) |
GYS2 |
rs1478290 |
upstream, ~3.5 Kb |
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| rs2306179 |
intron 5 |
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| rs10505873 |
intron 3 |
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| phosphofructokinase, liver |
PFKL |
rs2838549 |
intron 8 |
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| phosphofructokinase, muscle |
PFKM |
rs2269935 |
~700 bp upstream |
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| pyruvate kinase, liver and RBC |
PKLR |
rs3762272 |
intron 2 |
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| pyruvate kinase, muscle |
PKM2 |
rs2856929 |
intron 7 (MT) |
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| Nuclear Signaling |
retinoic acid receptor, alpha |
RARA |
rs4890109 |
intron 3 |
|
| rs9904270 |
~7.5 kb upstream |
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| retinoic acid receptor, beta |
RARB |
rs2033447 |
intron 2 (MT) |
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| rs1290443 |
intron 3 (MT) |
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| rs322695 |
~100 kb upstream |
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| retinoic acid receptor, gamma |
RARG |
rs10082776 |
intron 2 (untranslated) |
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| retinoid X receptor, alpha |
RXRA |
rs4917348 |
~100 kbp upstream |
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| rs3750546 |
~100 kb upstream |
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| rs3118536 |
intron 3 |
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| retinoid X receptor, gamma |
RXRG |
rs157864 |
intron 4 |
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| Adipocyte Regulation |
Adipokine-related |
adiponectin receptor 2 |
ADIPOR2 |
rs2058112 |
intron 1 (untranslated?) |
| rs7975375 |
intron 1 (untranslated?) |
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| angiotensin II receptor, type 1 |
AGTR1 |
rs12695902 |
intron 3 |
||
| rs931490 |
intron 2 (untranslated?), (MT) |
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| angiotensin II receptor, type 2 |
AGTR2 |
rs5950584 |
~4.5 kb upstream |
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| resistin |
RETN |
rs3219177 |
intron 1 |
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| Lipid Metabolic |
apolipoprotein E |
APOE |
rs7412 |
exon 3, C176R, *2–>*3 |
|
| rs429358 |
exon 3, R130C, *4–>*3 |
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| rs405509 |
~200 bp upstream |
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| rs439401 |
~1.5 kbp downstream |
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| rs446037 |
~1.5 kbp upstream |
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| cholesteryl ester transfer protein, plasma |
CETP |
rs5883 |
exon 9, F287F |
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| rs1532624 |
intron 7 |
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| rs3764261 |
~2.6 kb upstream |
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| rs5880 |
nonsynonymous, P390A |
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Seip et al. Nutrition & Metabolism 2008 5:4 doi:10.1186/1743-7075-5-4 |
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