Figure 5.

Conservation of pharmacological pathways and consistency amongst groups of animals are shown. NAD or resveratrol is known to activate SIRT-1. Conversely, sirtinol is an inhibitor of SIRT-1. Vaticanol B (Vat B) is a resveratrol tetramer natural product predicted to activate SIRT-1 as well (A). Isoproterenol or norepinephrine activation of beta-adrenergic receptors causes a decrease in detectable fat. Conversely, activation of PPARγ promotes adipocyte diferentation as predicted for treated zebrafish larvae. This slows the normal reduction in fat stores seen during this window of development.