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The levels of albumin, total protein and total bilirubin after the treatment of rats with antituberculosis drugs and silymarin. |
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| Groups |
Albumin (gr/dl) |
Total Protein (gr/dl) |
Total Bilirubin (mg/dl) |
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|
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| I (control) |
4.20 ± 0.40 |
7.27 ± 0.32 |
0.095 ± 0.022 |
| II (silymarin control) |
4.42 ± 0.40 |
7.49 ± 0.34 |
0.099 ± 0.021 |
| III (INH+RIF) |
3.44 ± 0.32* |
5.80 ± 0.59* |
0.194 ± 0.052* |
| IV (INH+RIF+PZA) |
3.35 ± 0.17* |
5.70 ± 0.48* |
0.199 ± 0.049* |
| V (INH+RIF+Silymarin) |
4.02 ± 0.28** |
6.84 ± 0.41** |
0.118 ± 0.036** |
| VI (INH+RIF+PZA+Silymarin) |
3.95 ± 0.47*** |
6.85 ± 0.59** |
0.137 ± 0.026** |
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Values represent mean ± SD. Constant doses of INH (50 mg/kg), RIF (100 mg/kg), PZA (350 mg/kg) and silymarin (200 mg/kg) were used. *P < 0.001 as compared to the controls (Groups I and II). ** P < 0.01 as compared to the controls (Groups I and II) and hepatotoxicity groups (Groups II and IV). *** P < 0.05 significant difference from the hepatotoxicity groups but not the control. | |||
Eminzade et al. Nutrition & Metabolism 2008 5:18 doi:10.1186/1743-7075-5-18 |
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