Influence of diet on body weight in B6 mice bearing the mouse CT-2A astrocytoma (A), and in SCID mice bearing the human U87 glioma (B). Tumors were implanted orthotopically at day 0, and diets were initiated at day 3 (arrow). The SD-UR, KC-UR, and KC-R represent the standard high carbohydrate diet fed unrestricted, the KetoCal® diet fed unrestricted, and the KetoCal® diet fed in restricted amounts, respectively. Values are expressed as the mean ± SEM (n = 12–14 mice per group), and asterisks indicate that the body weights of the KC-R mice (▴) were significantly lower than those of the unrestricted control groups at P < 0.01.
Zhou et al. Nutrition & Metabolism 2007 4:5 doi:10.1186/1743-7075-4-5