Table 2

Final body weights, blood glucosse concentrations, and peripheral nerve or serum parameters in non-diabetic and diabetic rats (3 weeks) sacrificed at the end of the diet-feeding experiment

Treatment

Non-diabetic

Diabetic

Diet

C

WR

BR

PR

C

WR

BR

PR

Group

C

WR

BR

PR

DC

DWR

DBR

DPR

Number of animals

4

6

6

6

4

9

9

9

Weight (g)

373.8 ± 7.8

374.7 ± 3.8

370.3 ± 9.1

384.8 ± 13.5

174.0 ± 8.6

174.2 ± 4.8

183.9 ± 2.7 ^b

209.0 ± 3.3 ^a*

Glucose (mg/dl)

127.0 ± 1.8

135.5 ± 2.7

129.0 ± 3.3

126.7 ± 4.0

438.0 ± 11.0

431.0 ± 9.3

405.2 ± 9.1

351.9 ± 6.3 ^a*

NCV (m/s)

50.4 ± 0.8

49.9 ± 1.3

50.2 ± 0.8

50.4 ± 0.9

34.0 ± 1.4

34.4 ± 0.8

37.9 ± 1.1

44.5 ± 1.3 ^a*

Na⁺/K⁺- ATPase (μmol/g/h)

6102.5 ± 218.9

4855 ± 463.4

6998 ± 515.6

6302 ± 371.5

2238 ± 102

2229.3 ± 153.0

2437.2 ± 189.9

3867.8 ± 177.6 ^a*

Homocysteine (μM)

6.3 ± 0.3

5.9 ± 0.1

6.1 ± 0.2

6.3 ± 0.2

3.3 ± 0.2

3.1 ± 0.2

4.2 ± 0.1 ^b*

5.3 ± 0.1 ^a*

PON 1 (nmol/ml/min)

224.0 ± 11.1

217.9 ± 4.4

216.0 ± 4.6

239.5 ± 6.5

118.4 ± 7.4

117.4 ± 5.9

158.3 ± 8.4 ^a

187.7 ± 13.6 ^a*

HTase (nmol/mg/min)

9.8 ± 0.4

10.0 ± 0.2

10.2 ± 0.3

10.3 ± 0.3

2.0 ± 0.3 ^c

1.8 ± 0.2 ^c

4.3 ± 0.2 ^b**

8.9 ± 0.2 ^a**

Creatinine (μmol/l)

67.3 ± 1.7

60.3 ± 1.6

59.7 ± 1.3 ^a*

59.5 ± 1.0 ^a*

89.3 ± 1.7

88.3 ± 1.1 ^a

82.5 ± 1.3 ^b*

72.8 ± 1.1 ^c*

One-way ANOVA was performed for 4 groups of non-diabetic treatment or diabetic treatment, followed by Tukey's multiple comparison test (if parametric). Difference vs. control (C group or DC group) was analyzed by Dunnet's multiple comparison test (*P < 0.01, **P,0.001). Kruskal-Wallis test was performed for the groups (if non-parametric) followed by Dunn's multiple comparison test. Values are means ± SEM. ^a,b,cValues with different superscript letters are significantly different among the same column at P < 0.01.

Usuki et al. Nutrition & Metabolism 2007 4:25   doi:10.1186/1743-7075-4-25