Table 3

MC4R mRNA and protein expression and MC3R mRNA expression in CNS regions involved in appetite regulation. Potential targets for POMC and AgRP neurones (references indicated numerically).

MCR locations:

MC4R mRNA

MC4R GFP expression

MC3R mRNA


Arcuate nucleus

90

105

93, 114, 118

Brainstem

90

105

-

PVN

90, 93

105

118

Lateral hypothalamus

90

105

118

DMH

90

105

118

SON

90

-

-

VMH

90

105

118

Periventricular nucleus

90

105

118

Nucleus accumbens

90

105

-

Amygdala

90

105

118


Millington Nutrition & Metabolism 2007 4:18   doi:10.1186/1743-7075-4-18

Open Data