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Stringent GeneSpring analysis of gene regulation in normal vs. tumor cells in response to 18 hr arginine deprivation. |
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| Class (n) |
Example |
Change in Normal |
Change in Tumor |
|
|
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| Cell Growth and Maintenance (10) |
growth arrest and DNA-damage-inducible 45 alpha Rattus norvegicus transcribed sequence with moderate similarity to protein sp:Q9H3K2 (H.sapiens) DER2_HUMAN Dermal papilla derived protein 2 (AA858928) neuronal cell death inducible putative kinase (NIPK) Caspase 12 tumor-associated protein 1 solute carrier family 7, member 1 solute carrier family 3, member 2 homocysteine-inducible, endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 asparagine synthetase CTL target antigen |
Inc |
Inc |
| Unclassified (1) |
Low density lipoprotein receptor |
Dec |
Dec |
| Cell Growth and Maintenance (28) |
retinoblastoma-like 2 epithelial calcium channel 1 sequestosome 1 70 kda heat shock protein precursor protein arginine N-methyltransferase 3(hnRNP methyltransferase S. cerevisiae)-like 3 eukaryotic translation initiation factor 4E binding protein 1 protease, serine, 15 B-cell translocation gene 1 5-hydroxytryptamine (serotonin) receptor 3a MAP-kinase phosphatase (cpg21) diphtheria toxin receptor |
NC |
Inc |
| Unclassified (24) |
growth arrest specific 5 |
||
| Cell Growth and Maintenance (12) |
cyclin dependent kinase inhibitor 2C solute carrier family 6, member 6 fatty acid Coenzyme A ligase, long chain 3 Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Topoisomerase (DNA) 2 alpha adducin 3, gamma |
NC |
Dec |
| Signal Transduction (2) |
RAB3D, member RAS oncogene family |
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| Developmental Processes (1) |
Sperm-associated antigen 5 arginine vasopressin receptor 1A GATA binding protein 6 |
||
| Unclassified (21) |
Nesprin-1 |
||
| Cell Growth and Maintenance (1) |
endo-alpha-mannosidase |
Inc |
NC |
| Signal Transduction (2) |
Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein Rattus norvegicus transcribed sequence with strong similarity to protein pir:I55595 (H. sapiens) I55595 splicing factor (BG372903) |
||
| Unclassified (7) |
transmembrane 4 superfamily member 3 (NM_133526) |
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| Cell Growth and Maintenance (6) |
cytochrome P450, subfamily 51 7-dehydrocholesterol reductase isopentenyl-diphosphate delta isomerase sterol-C4-methyl oxidase-like] farensyl diphosphate synthase Growth Response protein CL-6 (Insig-1) |
Dec |
NC |
|
'Change' defined as 2 fold and higher increase (+) or decrease (-) in expression from + arg to - arg. 'NC' (No change) defined as all other genes that were not differentially expressed with a 2 fold and higher change. Main functional classes are shown in the table, with corresponding representative genes in each class. Categorization of genes was performed using GeneSpring software. The number of genes in each class is also shown beside the class in parentheses. | |||
Leong et al. Nutrition & Metabolism 2006 3:37 doi:10.1186/1743-7075-3-37 |
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