Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatic analysis

doi:10.1186/1743-7075-3-37

Nutrition & Metabolism
Volume 3

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Leong HX
Simkevich C
Lesieur-Brooks A
Lau BW
Fugere C
Sabo E
Thompson NL

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Lesieur-Brooks A
Lau BW
Fugere C
Sabo E
Thompson NL
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Brief communication

Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: microarray bioinformatic analysis

Hwei Xian Leong¹ , Carl Simkevich² , Anne Lesieur-Brooks¹ , Bonnie W Lau³ , Celine Fugere¹ , Edmond Sabo³ and Nancy L Thompson¹

¹Division of Hematology and Oncology, Dept. of Medicine, Rhode Island Hospital – Brown Medical School, Providence, RI, USA

²COBRE Center for Genetics and Genomics, Division of Biology and Medicine, Brown University, Providence, RI, USA

³Dept. Pathology and Laboratory Medicine, Rhode Island Hospital – Brown Medical School, Providence, RI, USA

author email corresponding author email

Nutrition & Metabolism 2006, 3:37doi:10.1186/1743-7075-3-37


Published:	8 September 2006

Additional files

Additional file 1:

Major functional classes of arginine-sensitive genes in normal hepatic cells. GeneSpring functional categories of arginine-responsive genes in normal hepatic cells based on 9-way comparison of three independent data sets. Numbers of genes in each class and subclass are shown in parentheses along with gene accession numbers. Increase (I) and Decrease (D) defined as a two fold or higher change in expression from + arg to - arg.

Format: XLS Size: 27KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 2:

Major functional classes of arginine-sensitive genes in hepatic tumor cells. GeneSpring functional categories of arginine-responsive genes in tumorigenic hepatic cells based on 9-way comparison of three independent data sets. Numbers of genes in each class and subclass are shown in parentheses along with gene accession numbers. Increase (I) and Decrease (D) defined as a two fold or higher change in expression from + arg to - arg.

Format: XLS Size: 61KB Download file

This file can be viewed with: Microsoft Excel Viewer