|
Binding kinetics for anti-human TC mAbs as measured by SPR |
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| MAb |
Isotype |
Epitope1 |
KD2 (nmol/L) |
Holo/apo specificity (-fold) |
|
|
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| 3–9 |
IgG1 |
1 |
0.03 |
1 |
| 3–11 |
IgG2a |
2a |
0.2 |
1 |
| TC7 |
IgG2a |
2a |
10 |
1 |
| 4–7 |
IgG2b |
2b |
0.5 |
3 |
| 5H2 |
IgG1 |
2b |
>100 |
4 |
| TC4 |
IgG1 |
3 |
5–10 |
1 |
| TC2 |
IgG1 |
4 |
1 |
1 |
| 3C12 |
IgG1 |
5 |
5 |
1 |
| 3C4 |
IgG1 |
6 |
none |
>100 |
|
1 Epitope nomenclature follows that given in ref. 15. Mab 3C4 was originally assigned the same epitope as TC2 (epitope 4). Based on additional data, it has been reassigned a new epitope 6. 2 Approximate KD values for apoTC. | ||||
Orning et al. Nutrition & Metabolism 2006 3:3 doi:10.1186/1743-7075-3-3 |
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