Table 2

Effects of 12 wk α-tocopherol supplementation (E+) or restriction (E-) on phylloquinone and MK-4 concentrations in plasma and tissue of rats^1,2,3
		Phylloquinone				MK-4
	E+ (100 mg all-rac-α-tocopherol)	Control (30 mg all-rac-α-tocopherol)	E- (<10 mg total tocopherol)	P	E+ (100 mg all-rac-α-tocopherol)	Control (30 mg all-rac-α-tocopherol)	E- (<10 mg total tocopherol)	P
	n = 10	n = 13	n = 10		n = 10	n = 13	n = 10

Plasma (pmol/mL)	7.4 ± 0.7^a	10.6 ± 0.8^b	8.7 ± 0.9^a	0.03	0.1 ± 0.3^a	1.7 ± 0.7^b	0.36 ± 0.1^b	0.04
Liver (pmol/g protein)	670 ± 79^a	698 ± 41^a	643 ± 91^a	0.86	ND⁴	0.9 ± 0.9	ND⁴	0.50
Spleen (pmol/g protein)	531 ± 58^a	531 ± 48^a	735 ± 77^b	0.04	163 ± 30^a	133 ± 19^a	153 ± 29^a	0.69

¹All 3 diets contained 460 μg phylloquinone/kg of diet ²Values are mean ± SEM ³Means with different superscript letters are significantly different, P <0.05 (ANOVA with Bonferroni Correction) ⁴Not detectable
Tovar et al. Nutrition & Metabolism 2006 3:29 doi:10.1186/1743-7075-3-29