|
Results of the association test of each SNP against the phenotypic variation residual from the regression of covariates in Table 3. Results significant at alpha ≤ 0.05 are indicated in bold. Also shown are the FDR corrected p-value, the degrees of freedom in the regression model, the regression coefficient indicating the size of the effect of the minor allele, and the minimum effect size for 80% power of detection, relative to the standard deviation. |
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| SNP |
Gene |
p-value |
FDR |
degf |
coeff |
power |
SNP type |
|
|
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| rs936960 |
LIPC |
0.7354 |
0.8011 |
47 |
0.351 |
2.08 |
intron 1 |
| rs417344 |
LIPC |
0.1322 |
0.5433 |
48 |
1.175 |
1.57 |
~5.5 kb upstream from LIPC |
| rs6083 |
LIPC |
0.6944 |
0.8011 |
37 |
-0.226 |
1.25 |
S215N |
| rs295 |
LPL |
0.5519 |
0.7843 |
44 |
-0.526 |
1.49 |
intron 6 |
| rs328 |
LPL |
0.1973 |
0.5744 |
51 |
-1.330 |
1.76 |
exon 9, *474S |
| rs10422283 |
LIPE |
0.1610 |
0.5433 |
41 |
0.916 |
1.24 |
intron 1 |
| rs1556478 |
LIPA |
0.7417 |
0.8011 |
33 |
0.228 |
1.29 |
intron 5 |
| rs6586179 |
LIPA |
0.2575 |
0.6321 |
43 |
-1.189 |
2.08 |
exon 1, R23G |
| rs4245232 |
LIPG |
0.1561 |
0.5433 |
43 |
0.906 |
1.50 |
~1.5 kb upstream |
| rs814628 |
LIPF |
0.0002 |
0.0059 |
43 |
-3.658 |
1.86 |
exon 4, Ala161>Thr |
| rs2287754 |
GYS1 |
0.6950 |
0.8011 |
33 |
-0.324 |
1.51 |
5' UTR |
| rs1478290 |
GYS2 |
0.4504 |
0.7843 |
57 |
-0.381 |
1.13 |
~3.5 Kb upstream |
| rs1871143 |
GYS2 |
0.5236 |
0.7843 |
38 |
-0.381 |
1.31 |
intron 11 |
| rs2306179 |
GYS2 |
0.0068 |
0.0610 |
42 |
-1.717 |
1.40 |
intron 5 |
| rs4688046 |
GSK3B |
0.5148 |
0.7843 |
42 |
-0.382 |
1.37 |
intron 3 |
| rs334555 |
GSK3B |
0.4553 |
0.7843 |
41 |
0.925 |
2.09 |
intron 1 |
| rs711752 |
CETP |
0.2127 |
0.5744 |
44 |
0.677 |
1.13 |
intron 1 |
| rs3764261 |
CETP |
0.6900 |
0.8011 |
39 |
0.263 |
1.36 |
~2.6 kb upstream |
| rs5880 |
CETP |
0.0782 |
0.4220 |
42 |
2.769 |
2.71 |
P390A |
| rs1532624 |
CETP |
0.5299 |
0.7843 |
49 |
0.339 |
1.12 |
intron 7 |
| rs5883 |
CETP |
0.0018 |
0.0237 |
54 |
-2.854 |
1.94 |
exon 9, synonymous |
| rs5070 |
APOA1 |
0.4406 |
0.7843 |
39 |
-0.454 |
1.41 |
Intron |
| rs4520 |
APOC3 |
0.4275 |
0.7843 |
36 |
-0.497 |
1.32 |
G34G |
| rs2071521 |
APOC3 |
0.9176 |
0.9176 |
43 |
-0.053 |
1.13 |
Upstream |
| rs694066 |
GAL |
0.0231 |
0.1557 |
54 |
2.105 |
2.22 |
intron 1 |
| rs1468271 |
NPY |
0.7401 |
0.8011 |
46 |
-0.378 |
2.43 |
intron 1 |
| rs26312 |
GHRL |
0.7832 |
0.8133 |
61 |
0.233 |
1.50 |
~1 kb upstream |
Ruaño et al. Nutrition & Metabolism 2006 3:20 doi:10.1186/1743-7075-3-20 |
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