Table 2

List of 15 genes and 27 SNPs studied for association with weight loss induced by a low CHO diet.
Gene Family or Pathway	Gene	SNP	N	mac	min	maj	Freq	Gene	Description	Sequence Context

Lipases	Hepatic lipase	rs936960	49	7	A	C	0.07	LIPC	lipase, hepatic	CAGAGCACGAGGCTGATTTTC [A/C]ATCCCAGTGTGGGCCACACC
		rs417344	50	13	T	C	0.13	LIPC	lipase, hepatic	TTTCCTAATTTTGCAGTTGAG [A/G]TTTAAGAGGTTGGGAACTGG
		rs6083	39	28	A	G	0.36	LIPC	lipase, hepatic	GTCTTTCTCCAGATGATGCCA [A/G]TTTTGTGGATGCCATTCATA
	Lipoprotein lipase	rs295	46	15	A	C	0.16	LPL	lipoprotein lipase	GATGCACCTACTAGACACCTA [A/C]TCTGCGCTAGATGGTGGGGG
		rs328	53	10	C	G	0.09	LPL	lipoprotein lipase	ACAAGTCTCTGAATAAGAAGT [C/G]AGGCTGGTGAGCATTCTGGG
	Hormone sensitive lipase	rs10422283	43	26	T	C	0.30	LIPE	lipase, hormone-sensitive	GGAAGGAACCTCGTACATCCT [A/G]CGGGGCAGTGGGGACAGCGT
	Lysosomal acid lipase	rs1556478	35	28	A	G	0.40	LIPA	lipase A, lysosomal acid, cholesterol esterase (Wolman disease)	CACGGAGACTTATGCACCAGA [A/G]TGAAATGCTGAGATGTTCTT
		rs6586179	45	7	T	C	0.08	LIPA	lipase A, lysosomal acid, cholesterol esterase (Wolman disease)	ACCCTGCATTCTGAGGGGTCT [A/G]GAGGGAAACTGACAGCTGTG
	Endothelial lipase	rs4245232	45	15	A	C	0.17	LIPG	lipase, endothelial	TAAAAAACTAAAGCCCGCCTG [A/C]GTCTTGTTAATGAATGATAG
	Gastric lipase	rs814628	45	9	A	G	0.10	LIPF	lipase, gastric	ATCGACTTCATTGTAAAGAAA [A/G]CTGGACAGAAGCAGCTACAC
Glycogen Synthases	Glycogen Synthase 1 (muscle)	rs2287754	35	16	A	G	0.23	GYS1	glycogen synthase 1 (muscle)	CGGGAAGCTTGCAAGACGCTC [A/G]GCTTCCTATTGCAAGACCGC
	Glycogen Synthase 2 (hepatic)	rs1478290	59	29	T	G	0.25	GYS2	glycogen synthase 2 (liver)	AATGTGGCTGAAGCCAAAAGC [A/C]TAATGAATGAGGGGAAGCCT
		rs1871143	40	23	T	G	0.29	GYS2	glycogen synthase 2 (liver)	AGCCAGGAGCTTTCCTGGGCG [A/C]TTTTTGTACAGGATCTCATT
		rs2306179	44	18	A	G	0.20	GYS2	glycogen synthase 2 (liver)	TTTCAGTAGGTTTGCAGGGAA [A/G]CCAACTCAAAGCTATATCTG
	Glycogen Synthase 3b	rs4688046	44	19	T	C	0.22	GSK3B	glycogen synthase kinase 3 beta	TAGTAAACTATTTCTTCCCAT [A/G]GGAGAAGATGGATTCTTTTC
		rs334555	43	7	C	G	0.08	GSK3B	glycogen synthase kinase 3 beta	AATTATATCTTATTATTAAAA [C/G]TCTACCAACTCAAAGCTTCC
HDL Homeostasis	CETP	rs711752	46	36	A	G	0.39	CETP	cholesteryl ester transfer protein, plasma	TTCAAGGTCAAGTTCTTTGGT [A/G]AGAAGGTCCTAGCTGCATTG
		rs3764261	41	20	T	G	0.24	CETP	cholesteryl ester transfer protein, plasma	AGTGAATGAGATAGCAGACAA [A/C]CCAGATGCCTACCGACAGGT
		rs5880	44	4	C	G	0.05	CETP	cholesteryl ester transfer protein, plasma	GATATCGTGACTACCGTCCAG [C/G]CCTCCTATTCTAAGAAAAGC
		rs1532624	51	33	T	G	0.32	CETP	cholesteryl ester transfer protein, plasma	TCTGCCCCTTTGGGCTGCAGC [A/C]TCACAAGCTGTGTGGCGTTG
		rs5883	56	8	T	C	0.07	CETP	cholesteryl ester transfer protein, plasma	AGCTACCTTGGCCAGCGAGTG [A/G]AAGACTCGCTCAGAGAACCA
	APOA1	rs5070	41	18	A	G	0.22	APOA1	apolipoprotein A-I	GCCACGGGGATTTAGGGAGAA [A/G]GCCCCCCGATGGTTGGCTCC
	APOC3	rs4520	38	23	T	C	0.30	APOC3	apolipoprotein C-III	CTTGGTGGCGTGCTTCATGTA [A/G]CCCTGCATGAAGCTGAGAAG
		rs2071521	45	37	T	C	0.41	APOC3	apolipoprotein C-III	ACAGCTCCTGTTGCCATAGGA [A/G]GGAGCTGGGTGAGATACTAG
Appetite Hormones	Galanin	rs694066	56	6	A	G	0.05	GAL	galanin	TTCTAAGTCCTCTGCCATGCC [A/G]GGAAAGCCTGGGTGCACCCA
	Neuro-peptide Y	rs1468271	48	5	A	G	0.05	NPY	neuropeptide Y	GACCCTGTAATTTTCAGAAAC [A/G]CACATAGGAGTGGGTGTCTG
	Ghrelin Precursor	rs26312	63	14	A	G	0.11	GHRL	ghrelin precursor	GCTGTTGCTGCTCTGGCCTCT [A/G]TGAGCCCCGGGAGTCCGCAG

SNP identification numbers (noted as "rs...") are the unique SNP identifiers from the NCBI dbSNP database. Also given are the number of patients with good genotype results (N), the number of minor alleles found (mac), and the corresponding allele frequency as observed in this study.
Ruaño et al. Nutrition & Metabolism 2006 3:20 doi:10.1186/1743-7075-3-20