Table 2

Observational Studies of Stearic Acid and Cardiovascular Outcomes

Author

Year

Study design

N, Population

Stearic acid assessment method

CHD/MI Outcomes

Other

Kromhout [141]

1995

Ecologic

12,763 men, 16 cohorts of 7CS

Dietary intake

↑ CHD mortality

Simon [68, 69]

1995

Prospective

96 cases, 96 controls, USA-MRFIT

Serum levels

↑ CHD incidence

Null-stroke incidence

Watts [67]

1996

Prospective

50 men, Australia

Dietary intake

↑ CAD progression

Hojo [61]

1998

Case-control

71 cases, 60 controls, Japan

Serum levels

Null-stenosis

Hu [65]

1999

Prospective

80,082 women, USA-nurses

Dietary intake

↑ CHD incidence

Yli-Jama [62]

2002

Case-control

103 cases, 104 controls, Norway

Serum levels

↓ MI incidence

Kabagambe [63]

2003

Case-control

485 cases, 508 controls, Costa Rica

Dietary intake

↑ MI incidence

Wang [66]

2003

Prospective

3591 whites, USA

Serum levels

↑ CHD mortality

Abbreviations: 7CS, 7 Countries Study; MRFIT, Multiple Risk Factor Intervention Trial;

* High stearic acid level among men from geographic areas of high IHD mortality

Ding et al. Nutrition & Metabolism 2006 3:2   doi:10.1186/1743-7075-3-2