|
Metabolic alterations in PEPCK-C-/- mice at two days of age. |
||||
| Body composition |
PEPCK-C+/+ |
(n) |
PEPCK-C-/- |
(n) |
|
|
||||
| % Water |
80.3 ± 0.30 |
3 |
79.26 ± 0.22 |
3 |
| % Fat |
3.48 ± 0.36 |
3 |
1.85 ± 0.57 |
3 |
| % Lean Mass |
16.42 ± 0.63 |
3 |
18.88 ± 0.78 |
3 |
|
|
||||
| Metabolites in liver |
||||
|
|
||||
| Triglyceride (μmoles/g) |
4.17 ± 1.00 |
5 |
9.58 ± 1.75 |
5 |
| Lactate (μmoles/g) |
0.19 ± 0.02 |
3 |
0.37 ± 0.09 |
3 |
| Malate (μmoles/g) |
0.24 ± 0.05 |
3 |
2.84 ± 1.58 |
3 |
|
|
||||
| Metabolites in plasma |
||||
|
|
||||
| Triglyceride (mg/dl) |
23.7 ± 6.3 |
3 |
36.3 ± 21.5 |
2 |
| Ammonia (μmoles/ml) |
0.14 ± 0.02 |
5 |
0.45 ± 0.28 |
4 |
| BUN (mg/dl) |
29.0 ± 7.0 |
2 |
65.5 ± 28.5 |
2 |
| Lactate (μmoles/ml) |
0.28 ± 0.13 |
3 |
0.72 ± 0.47 |
3 |
| β-Hydoxybutyrate (μmoles/ml) |
5.83 ± 0.21 |
3 |
17.95 ± 0.70 |
3 |
|
The values are expressed as the mean ± S.E. for the number of animals shown in parenthesis | ||||
Hakimi et al. Nutrition & Metabolism 2005 2:33 doi:10.1186/1743-7075-2-33 |
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