|
Examples of genes regulated by GR |
|||
| Gene Names |
Function |
Regulation |
Reference |
|
|
|||
| Glutamine synthetase |
Amino acid metabolism |
Up |
42 |
| TAT |
Amino acid catabolism |
Up |
43, 44 |
| Tryptophan oxygenase |
Amino acid catabolism |
Up |
45 |
| PEPCK (liver) |
Gluconeogenesis |
Up |
46 |
| G6Pase |
Gluconeogenesis |
Up |
47, 48 |
| Angiotensinogen |
Precursor of angiotensin I; vasoconstriction, electrolyte balance, etc. |
Up |
49 |
| Leptin |
Energy metabolism |
Up |
50 |
| VLDLR |
Lipoprotein metabolism |
Up |
51 |
| PEPCK (adipose) |
Glyceroneogenesis |
Down |
52 |
| aP2 |
Intracellular lipid shuttling and metabolism |
Up |
53 |
| GLUT4 |
Glucose transport |
Up |
53 |
| HSL |
Lipolysis |
Up |
53 |
| LPL |
Lipid metabolism |
Up |
53 |
| TNF-α |
Inflammation and apoptosis |
Down |
53 |
| Osteocalcin |
Marker for mature osteoblasts |
Down |
54, 55 |
| CRH |
Stress mediated/feedback hormone release |
Down |
56 |
| POMC |
Precursor of pituitary hormones |
Down |
57, 58 |
| Prolactin |
Hormone critical for reproduction |
Down |
59 |
| Proliferin |
Angiogenesis |
Down |
60, 61 |
| Glycoprotein hormone α-subunit |
Common subunit of gonadotropin hormones |
Down |
62, 63 |
| IL-6 |
Proinflammatory cytokine |
Down |
64 |
| IL-8 |
Proinflammatory cytokine |
Down |
65 |
| Collagenase |
Matrix protease |
Down |
66 |
| ICAM-1 |
Inflammatory response |
Down |
39 |
|
Abbreviations: TAT, tyrosine aminotransferase; PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; VLDLR, very low density lipoprotein receptor; aP2, adipocyte fatty acid binding protein or A-FABP; GLUT-4, glucose transporter 4; HSL, hormone sensitive lipase; LPL, lipoprotein lipase; TNF-α, tumor necrosis factor α; CRH, corticotrophin-releasing hormone; POMC, proopiomelanocortin; IL-6, interleukin 6; IL-8, interleukin 8; ICAM-1, intercellular adhesion molecule 1. | |||
Wang Nutrition & Metabolism 2005 2:3 doi:10.1186/1743-7075-2-3 |
|||