Table 5

Ratio of RANKL/OPG in Osteoclasts and Osteoblasts in Rats on 50% NR Mg Diet


50% NR


Osteoclast
Osteoblast

3 Month Control
0.24
0.12
3 Month 25% NR
0.30
0.42
6 Month Control
0.13
0.02
6 Month 50% NR
3.13
0.32

As shown in Table 5, the ratio of RANKL to OPG was increased in Mg deficient animals relative to controls in both cell types which favors osteoclastogenesis.

Rude et al. Nutrition & Metabolism 2005 2:24   doi:10.1186/1743-7075-2-24