Table 3

Ratio of RANKL/OPG in Osteoclasts and Osteoblasts in Rats on 25% NR Mg Diet


25% NR


Osteoclast
Osteoblast

2 Month Control
2.32
9.82
2 Month 25% NR
108
18.75
4 Month Control
3.41
4.88
4 Month 25% NR
50
25
6 Month Control
3.12
2.12
6 Month 25% NR
54
31

As shown in Table 3, the ratio of RANKL to OPG was increased in Mg deficient animals relative to controls in both cell types which favors osteoclastogenesis.

Rude et al. Nutrition & Metabolism 2005 2:24   doi:10.1186/1743-7075-2-24