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Ratio of RANKL/OPG in Osteoclasts and Osteoblasts in Rats on a .04% NR Diet |
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| Osteoclast |
Osteoblast |
|
|
|
||
| Day 1 Control |
1 |
0.44 |
| Day 1 .04% NR |
0.4 |
.046 |
| Day 3 Control |
0.6 |
0.55 |
| Day 3 .04% NR |
0.51 |
0.24 |
| Day 8 Control |
1 |
0.44 |
| Day 8 .04% NR |
0.25 |
0.33 |
| Day 15 Control |
1.25 |
0.29 |
| Day 15 .04% NR |
0.79 |
0.38 |
| Day 22 Control |
0.65 |
0.05 |
| Day 22 .04% NR |
0.12 |
0.25 |
| Day 28 Control |
.029 |
0.12 |
| Day 28 .04% NR |
.052 |
0.16 |
| Day 84 Control |
.096 |
0.14 |
| Day 84 .04% NR |
0.256 |
1.66 |
|
As shown in Table 1 there is no apparent excess of RANKL relative to OPG in rats on a diet containing .04% of NR until after day 22. | ||
Rude et al. Nutrition & Metabolism 2005 2:24 doi:10.1186/1743-7075-2-24 |
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