Table 1

Selected hepatic PPARα regulated genes with at least one functional peroxisome proliferator receptor element (PPRE) identified within the promoter sequence

Gene
Function
Species
References

Acyl CoA binding protein
fatty acyl-CoA ester transport
rat
127
Acyl CoA oxidase
peroxisomal β-oxidation
rat, human
128-130
Apolipoprotein-AI and AII
plasma HDL metabolism
human, mouse, rat
131-134
Apolipoprotein-AV
plasma triglyceride metabolism
human
134
Apolipoprotein-CIII
plasma HDL metabolism
rat
135
Bifunctional enzyme
peroxisomal β-oxidation
rat
136
Carnitine palmitoyl transferase-I and -II
mitochondrial β-oxidation
human, mouse, rat, hamster
132, 137-139
Cytochrome P450 enzymes
fatty acid and cholesterol metabolism
rat, mouse, human
130, 141-145
Δ6- and Δ5-desaturase
desaturation of fatty acyl-CoA
mouse
146
Fatty acid binding protein
fatty acid binding/transport
mouse
147
Fatty acid transport protein and translocase
fatty acid transport
mouse
148, 149
Lipoprotein lipase
triglyceride clearance
mouse
148, 149
Liver X receptor α
cholesterol metabolism
mouse
150, 151
Long-chain acyl-CoA synthetase
fatty acid activation
human, mouse
139, 152
Malic enzyme
fatty acid synthesis
mouse, rat
153, 154
Mitochondrial HMG-CoA synthase
ketogenesis
rat, human
152, 155
Medium-chain acyl-CoA dehydrogenase
mitochondrial β-oxidation
mouse
138, 139
Phospholipid transfer protein
HDL metabolism
human
156
Stearoyl-CoA desaturase-1
desaturation of fatty acyl CoA
mouse
157
Superoxide dismutase
free radical metabolism
rat
158
Thiolase B
mitochondrial β-oxidation
rat
159
Transferrin
iron transport
human
160
Very long- and long-chain acyl CoA dehydrogenases
mitochondrial β-oxidation
mouse
139

Abbreviations: HDL, high density lipoprotein; HMG-CoA, hydroxymethylglutaryl-Coenzyme A

Fatehi-Hassanabad and Chan Nutrition & Metabolism 2005 2:1   doi:10.1186/1743-7075-2-1