Table 1

Liver RNA-seq results from WD + AF rats versus WD rats when both groups were compared to CTL rats (p < 0.01)
Gene Gene function* WD + AF/CTL Fold-change WD/CTL Fold-change
Efna5 Functions in pancreatic islet cells to regulate glucose-stimulated insulin secretion -2.20 -1.37
Ahr Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons -1.93 -1.35
Pck1 Main control point for the regulation of gluconeogenesis -1.90 -1.31
Sall1 Transcriptional repressor involved in organogenesis -1.88 -1.41
Rasgef1b Guanine nucleotide exchange factor with specificity for Rap2a and other Ras family proteins -1.87 -1.35
Acadsb Member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. -1.65 -1.31
Tmem56 Unknown function -1.62 -1.09
Ivns1abp Protects cells from cell death induced by actin destabilization -1.58 -1.08
Slc2a2 Mediates facilitated bidirectional glucose transport (a.k.a. Glut2) -1.56 -1.22
Hspa13 Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins -1.56 -1.11
Bach1 Plays important roles in coordinating transcription activation and repression by Mafk -1.52 -1.28
C21orf91 Unknown function -1.51 -1.16
Adcy9 Membrane bound enzyme that catalyses the formation of cyclic AMP from ATP 1.55 1.32
Cd36 Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport 1.61 1.55
Slc39a4 Plays an important role in cellular zinc homeostasis as a zinc transporter 1.69 1.33
Foxa2 Encodes a member of the forkhead class of DNA-binding proteins, and can control the expression of liver-specific genes such as albumin 1.69 1.29
Ces2 Participate in fatty acyl and cholesterol ester metabolism 1.73 1.41
Ltb Plays a specific role in immune response regulation 1.83 1.49
Nr0b2 Inhibits transcriptional activity of Neurod1 on E-box-containing promoter 2.99 2.39

Legend: bold-faced fold-change values indicate that genes that were altered by WD + AF but were not altered with WD when both conditions compared to CTL rats. * = descriptions adapted from http://www.genecards.org webcite.

Mobley et al.

Mobley et al. Nutrition & Metabolism 2014 11:19   doi:10.1186/1743-7075-11-19

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