Table 1

Effect of MTX and glutamine on intestinal mucosal parameters
Paramaters/Groups CONTR CONTR-GLN MTX MTX-GLN
Bowel weight (mg/cm/100 g BW)
Jejunum 22.6 ± 0.9 21.3 ± 0.5 20.3 ± 0.4* 19.7 ± 1.3
Ileum 20.0 ± 0.9 19.0 ± 0.8 18.3 ± 0.8* 20.3 ± 1.1†
Mucosal weight (mg/cm/100 g BW)
Jejunum 9.7 ± 0.6 10.1 ± 0.6 6.9 ± 0.5* 8.2 ± 0.6*†
Ileum 9.0 ± 0.5 8.4 ± 0.3 7.2 ± 0.2* 9.1 ± 0.7†
Mucosal DNA (μg/cm/100 g BW)
Jejunum 4.5 ± 0.4 4.2 ± 1.4 1.6 ± 0.4* 1.6 ± 0.2*
Ileum 7.4 ± 0.8 5.5 ± 1.5 5.2 ± 0.5* 5.2 ± 0.6*
Mucosal protein (μg/cm/100 g BW)
Jejunum 160 ± 13 184 ± 30 132 ± 7* 163 ± 12†
Ileum 166 ± 8 174 ± 21 130 ± 11* 168 ± 16†

CONTR-control, GLN-glutamine, MTX-methotrexate.

*P < 0.05 vs control, †P < 0.05 MTX-GLN vs MTX.

Sukhotnik et al.

Sukhotnik et al. Nutrition & Metabolism 2014 11:17   doi:10.1186/1743-7075-11-17

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