Control of glucokinase. Binding of glucokinase-regulatory protein (RP) reduces the activity of glucokinase (GK). Fructose-1-P relieves the inhibition by stabilizing the dissociated RP, while F-6-P furthers inhibition by stabilizing the complex. Not shown in the figure: the GK-RP complex is transported to the nucleus . Dissociation leads to transport from the nucleus.
Feinman and Fine Nutrition & Metabolism 2013 10:45 doi:10.1186/1743-7075-10-45