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Short-term role of the dietary total antioxidant capacity in two hypocaloric regimes on obese with metabolic syndrome symptoms: the RESMENA randomized controlled trial

Patricia Lopez-Legarrea1, Rocio de la Iglesia1, Itziar Abete24, Isabel Bondia-Pons1, Santiago Navas-Carretero14, Lluis Forga3, J Alfredo Martinez14* and M Angeles Zulet14

Author Affiliations

1 Department of Nutrition, Food Science and Physiology, University of Navarra, Irunlarrea rd 1, Pamplona, 31008, Spain

2 Biodonostia Health Research Institute, Doctor Begiristain rd (no number), San Sebastian, 20014, Spain

3 Hospital Complex of Navarra, Irunlarrea rd 3, Pamplona, 31008, Spain

4 CIBERobn. Carlos III Health Research Institute, Madrid, Spain

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Nutrition & Metabolism 2013, 10:22  doi:10.1186/1743-7075-10-22

Published: 13 February 2013



Dietary strategies seem to be the most prescribed therapy in order to counteract obesity regarding not only calorie restriction, but also bioactive ingredients and the composition of the consumed foods. Dietary total antioxidant capacity (TAC) is gaining importance in order to assess the quality of the diet.


Ninety-six obese adults presenting metabolic syndrome (MetS) symptoms completed an 8-week intervention trial to evaluate the effects of a novel dietary program with changes in the nutrient distribution and meal frequency and to compare it with a dietary pattern based on the American Heart Association (AHA) guidelines.

Anthropometric and biochemical parameters were assessed at baseline and at the endpoint of the study, in addition to 48-hours food dietary records.


Both diets equally (p > 0.05) improved MetS manifestations. Dietary TAC was the component which showed the major influence on body weight (p = 0.034), body mass index (p = 0.026), waist circumference (p = 0.083) and fat mass (p = 0.015) reductions. Transaminases (ALT and AST) levels (p = 0.062 and p = 0.004, respectively) were associated with lower TAC values.


RESMENA diet was as effective as AHA pattern for reducing MetS features. Dietary TAC was the most contributing factor involved in body weight and obesity related markers reduction.

Trial registration; NCT01087086 webcite

Antioxidant; Weight loss; Energy restriction; Macronutrient distribution; Dietary components; Nutritional profile