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Metabolic aspects of low carbohydrate diets and exercise

Sandra J Peters* and Paul J LeBlanc

Author Affiliations

Faculty of Applied Health Sciences, Brock University, St. Catharines, ON, Canada L2S 3A1

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Nutrition & Metabolism 2004, 1:7  doi:10.1186/1743-7075-1-7

Published: 30 September 2004


Following a low carbohydrate diet, there is a shift towards more fat and less carbohydrate oxidation to provide energy to skeletal muscle, both at rest and during exercise. This review summarizes recent work on human skeletal muscle carbohydrate and fat metabolic adaptations to a low carbohydrate diet, focusing mainly on pyruvate dehydrogenase and pyruvate dehydrogenase kinase, and how these changes relate to the capacity for carbohydrate oxidation during exercise.