|
The positive effects of eNOS and eNO |
| • Promotes vasodilatation of vascular smooth muscle. |
| • Counteracts smooth muscle cell proliferation. |
| • Decreases platelet adhesiveness. |
| • Decreases adhesiveness of the endothelial layer to monocytic WBCs (the "teflon effect"). |
| • Anti-inflammatory effect. |
| • Anti-oxidant effect. It scavenges reactive oxygen species locally, and acts as a chain-breaking antioxidant to scavenge ROS. |
| • Anti-fibrotic effect. When NO is normal or elevated, MMPs are quiescent; conversely if NO is low, MMPs are elevated and active. |
| MMPs are redox sensitive. |
| • No inhibits prooxidant actions of uric acid during copper-mediated LDL oxidation. |
| • NO has diverse anti-atherosclerotic actions on the arterial vessel wall including antioxidant effects by direct scavenging of ROS – RNS acting as chain-breaking antioxidants and it also has anti-inflammatory effects. |
Hayden and Tyagi Nutrition & Metabolism 2004 1:10 doi:10.1186/1743-7075-1-10 |